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PF-05180999 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755349

MBS5755349 is an inhibitor targeting PF-05180999. PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-05180999, Inhibitor
Full Product Name
PF-05180999
Product Gene Name
PF-05180999, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
414.39
Solubility
DMSO: 50mg/mL (120.66mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H17F3N8
SMILES
CC1=NC(C2=C(C3=CC=C(C(F)(F)F)C=N3)N(C)N=C2)=C4N1N=CN=C4N5CCC5
CAS Number
1394033-54-5
Target & IC50
PDE2A: ic50 1.6nM
PDE10A1: ic50
PDE11A4: ic50
PDE7B: ic50
In Vitro
PF-05180999 induces acute and exposure-dependent elevation in the accumulation of cGMP bulk levels in the cortex, striatum, and hippocampus, but with no changes in cAMP and the associated downstream phospho-cAMP response element-binding protein (p-CREB) in mice. PF-05180999 (0.032-0.32mg/kgmg/kg, s.c.) dramatically decreases the working memory errors produced by ketamine in a working memory radial arm maze (RAM) model in rats [1].

Product Categories/Family for PF-05180999, inhibitor

Metabolism; PDE

Structure of PF-05180999, inhibitor

PF-05180999 Inhibitor – Cat# MBS5755349

Product References and Citations for PF-05180999, inhibitor

Helal CJ, et al. Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem. 2018 Feb 8;61(3):1001-1018.
Helal CJ, et al. Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem. 2018 Feb 8;61(3):1001-1018.

Other Notes

Small volumes of PF-05180999, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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