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PF-06471553 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755354

PF-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (IC50: 92nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-06471553, Inhibitor
Full Product Name
PF-06471553
Product Gene Name
PF-06471553, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
467.54
Solubility
DMSO: 150mg/mL (320.83mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H25N5O4S
SMILES
O=S(C1=CC2=C(CN(C(CC3=CC=CC(OC)=C3)=O)C2)C=C1)(NC4=NN(C5CCC5)N=C4)=O
CAS Number
1808094-07-6
Target & IC50
MGAT3: ic50 92nM
In Vitro
In hMGAT3 mice, PF-06471553 (200mg/kg, p.o.) in addition to (DGAT1 and DGAT2) inhibitors display additional inhibition of glycerol-d5 incorporated triolein. It has no effect on WT mice[1].

Structure of PF-06471553, inhibitor

PF-06471553 Inhibitor – Cat# MBS5755354

Product References and Citations for PF-06471553, inhibitor

Huard K, et al. Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase J Med Chem. 2015 Sep 24;58(18):7164-72.
Huard K, et al. Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem. 2015 Sep 24;58(18):7164-72.

Other Notes

Small volumes of PF-06471553, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06471553 purchase

MBS5755354 is an inhibitor targeting PF-06471553.
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