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PGMI-004A Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755368

PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1uM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGMI-004A, Inhibitor
Full Product Name
PGMI-004A
Product Gene Name
PGMI-004A, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
463.38
Solubility
DMSO: 125mg/mL (269.76mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H12F3NO6S
SMILES
O=S(C(C=C1C2=O)=C(O)C(O)=C1C(C3=C2C=CC=C3)=O)(NC4=CC=C(C(F)(F)F)C=C4)=O
CAS Number
1313738-90-7
Target & IC50
PGAM1: ic50 13.1uM
In Vitro
PGMI-004A treatment, causes significantly decreased tumor growth and tumor size in treated mice compared with mice receiving vehicle control. treatment with PGMI-004A effectively inhibits PGAM1 enzyme activity in tumors in vivo in resected tumors from xenograft nude mice. The xenograft experiment is performed by injecting H1299 cells to nude mice. Six days post-injection, mice are divided into two groups (n=8/group) and treated with either PGMI-004A (100mg/kg/day) or vehicle for 21 days [1].

Structure of PGMI-004A, inhibitor

PGMI-004A Inhibitor – Cat# MBS5755368

Product References and Citations for PGMI-004A, inhibitor

Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

Other Notes

Small volumes of PGMI-004A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGMI-004A purchase

MBS5755368 is an inhibitor targeting PGMI-004A.
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