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PhiKan083 Inhibitor – Phikan 083

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755373

MBS5755373 is an inhibitor targeting PhiKan083. Also known as PhiKan 083. PhiKan 083 is a carbazole derivative More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PhiKan 083 (PhiKan083), Inhibitor
Full Product Name
PhiKan 083
Product Gene Name
Form/Format
Solid. Powder
Purity/Purification
98.20%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
238.33
Solubility
DMSO: 115mg/mL (482.52mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
Ethanol: 100mg/mL (419.59mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C16H18N2
SMILES
CCN1C2=CC=CC=C2C2=C1C=CC(CNC)=C2
CAS Number
880813-36-5
Target & IC50
p53-Y220C: ic50 167uM (Kd)
p53Y220C, in Ln229 cells: ic50 150uM (Kd)
p53/MDM2

Product Categories/Family for PhiKan083, inhibitor

Structure of PhiKan083, inhibitor

PhiKan083 Inhibitor – Cat# MBS5755373

Product References and Citations for PhiKan083, inhibitor

Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.
Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.
Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.
Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.
Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74.
Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74.

Other Notes

Small volumes of PhiKan083, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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