BF738735 Inhibitor

Name: BF738735 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755378
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755378

BF738735 is an inhibitor of phosphatidylinositol 4-kinase III beta (IC50: 5.7nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BF738735, Inhibitor

Full Product Name

BF738735

Product Gene Name

BF738735, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

426.46

Solubility

DMSO: 125mg/mL (293.11mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H19FN4O3S

SMILES

OC1=CC=C(C2=C(C)N=C3C(NCC4=CC=CC(S(=O)(C)=O)=C4)=NC=CN32)C=C1F

CAS Number

1436383-95-7

Target & IC50

PI4KIIIbeta: ic50 5.7nM
PI4KIIIalpha: ic50 1.7uM

In Vitro

BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation. A complete inhibition with 25mg/kg and some inhibition with 5mg/kg dose is observed[2].

Product Categories/Family for BF738735, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for BF738735, inhibitor

van der Schaar HM, et al. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIbeta. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81.
van der Schaar HM, et al. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIbeta. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81.
V Saarnio. Antiviral Molecules of Enteroviruses. 13.1.2017.
V Saarnio. Antiviral Molecules of Enteroviruses. 13.1.2017.

Other Notes

Small volumes of BF738735, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BF738735 purchase

MBS5755378 is an inhibitor targeting BF738735.