PICO145 Inhibitor

Name: PICO145 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755380
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755380

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (-)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pico145, Inhibitor

Full Product Name

Pico145

Product Gene Name

Pico145, inhibitor

Product Synonym Names

HC-608

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

524.88

Solubility

DMSO: 100mg/mL (190.52mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H20ClF3N4O5

SMILES

O=C1C2=C(N=C(OC3=CC=CC(OC(F)(F)F)=C3)N2CC4=CC=C(Cl)C=C4)N(C)C(N1CCCO)=O

CAS Number

1628287-16-0

Target & IC50

TRPC4, cell assay: ic50 0.349nM
TRPC5, cell assay: ic50 1.3nM
TRPC4-TRPC1, cell assay: ic50 0.03nM
TRPC5-TRPC1, cell assay: ic50 0.2nM

Product Categories/Family for Pico145, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Product References and Citations for Pico145, inhibitor

Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J Biol Chem. 2017 May 19;292(20):8158-8173.
Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J Biol Chem. 2017 May 19;292(20):8158-8173.

Other Notes

Small volumes of Pico145, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pico145 purchase

MBS5755380 is an inhibitor targeting Pico145.