Pironetin Inhibitor

Name: Pironetin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755388
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755388

Pironetin binds to alpha-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an alpha/beta unsaturated lactone isolated from Streptomyces species. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pironetin, Inhibitor

Full Product Name

Pironetin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

324.45

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H32O4

SMILES

O=C1C=C[C@H]([C@H](O1)C[C@H]([C@@H]([C@@H]([C@H](C/C=C/C)C)OC)C)O)CC

CAS Number

151519-02-7

Target & IC50

Microtubule

In Vitro

Pironetin (0.78-6.25mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment displays a moderate antitumor effect. However, a severe weight loss is observed as a side effect[1].

Product Categories/Family for Pironetin, inhibitor

Cytoskeletal Signaling; Microtubule Associated

Product References and Citations for Pironetin, inhibitor

Kondoh M, et al. Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett. 1998 Apr 10;126(1):29-32.
Kondoh M, et al. Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett. 1998 Apr 10;126(1):29-32.
Yang J, et al. Pironetin reacts covalently with cysteine-316 of alpha-tubulin to destabilize microtubule. ] Nat Commun. 2016 Jun 30;7:12103.
Yang J, et al. Pironetin reacts covalently with cysteine-316 of alpha-tubulin to destabilize microtubule. ] Nat Commun. 2016 Jun 30;7:12103.

Other Notes

Small volumes of Pironetin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pironetin purchase

MBS5755388 is an inhibitor targeting Pironetin.