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PK11195 Inhibitor – Pk 11195

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755389

PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2uM, 8.2uM, 3.5uM for L. amazonensis, L. major and L. braziliensis, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PK 11195 (PK11195), Inhibitor
Full Product Name
PK 11195
Product Gene Name
PK11195, inhibitor
Product Synonym Names
RP 52028
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
352.86
Solubility
DMSO: 62.5mg/mL (177.12mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H21ClN2O
SMILES
O=C(N(C(CC)C)C)C1=CC2=CC=CC=C2C(C3=CC=CC=C3Cl)=N1
CAS Number
85532-75-8
Target & IC50
L. amazonensis: ic50 14.2uM
L. major: ic50 8.2uM
L. braziliensis: ic50 3.5uM
In Vitro
The selective index value for L. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK 11195[1].

Structure of PK11195, inhibitor

PK11195 Inhibitor – Cat# MBS5755389

Product References and Citations for PK11195, inhibitor

Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.
Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.

Other Notes

Small volumes of PK11195, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PK11195 purchase

MBS5755389 is an inhibitor targeting PK11195. Also known as PK 11195.
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