PNU-142633 Inhibitor

Name: PNU-142633 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755395
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755395

PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6nM and > 18 000nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PNU-142633, Inhibitor

Full Product Name

PNU-142633

Product Gene Name

PNU-142633, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

422.52

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C24H30N4O3

SMILES

O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(C(N)=O)C=C4)CC3)=C1)NC

CAS Number

187665-65-2

Target & IC50

5-HT1D Receptor: ic50 6nM (ki)

In Vitro

PNU-142633 fails to alter resistance in these vascular beds. PNU-142633 (0.03-1mg/kg; intravenous injection; male Hartley guinea pigs) treatment,blocks neurogenic plasma protein extravasation [1].

Product Categories/Family for PNU-142633, inhibitor

GPCR/G Protein; 5-HT Receptor; Neuroscience

Product References and Citations for PNU-142633, inhibitor

McCall RB, et al. Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-14263Cephalalgia. 2002 Dec;22(10):799-806.
McCall RB, et al. Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia. 2002 Dec;22(10):799-806.
Gomez-Mancilla B, et al. Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine. Cephalalgia. 2001 Sep;21(7):727-32.
Gomez-Mancilla B, et al. Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine. Cephalalgia. 2001 Sep;21(7):727-32.

Other Notes

Small volumes of PNU-142633, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PNU-142633 purchase

MBS5755395 is an inhibitor targeting PNU-142633.