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Pyridoclax Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755426

MBS5755426 is an inhibitor targeting Pyridoclax. Pyridoclax is an inhibitor of potential Mcl-1. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pyridoclax, Inhibitor
Full Product Name
Pyridoclax
Product Synonym Names
MR-29072
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
426.51
Solubility
DMSO: 20mg/mL (46.89mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H22N4
SMILES
CC1=CC(C2=NC=C(C3=CC=CN=C3)C=C2/C=C/C4=CC=CC=C4)=CN=C1C5=CC=CN=C5
CAS Number
1651890-44-6
Target & IC50
Mcl-1
In Vitro
Pyridoclax directly binds to Mcl-1. Pyridoclax induces apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Pyridoclax causes apoptosis in ovarian, and also in lung, and mesothelioma cancer cells when it is administrated in combination with Bcl-xL-targeting siRNA or Bcl-xL targeting molecules such as ABT-737 or its orally available derivative ABT-263. Pyridoclax sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies [1][2].

Product Categories/Family for Pyridoclax, inhibitor

Apoptosis; BCL

Structure of Pyridoclax, inhibitor

Pyridoclax Inhibitor – Cat# MBS5755426

Product References and Citations for Pyridoclax, inhibitor

Gloaguen C, et al. First evidence that oligopyridines, alpha-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68.
Gloaguen C, et al. First evidence that oligopyridines, alpha-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68.
Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.
Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.

Other Notes

Small volumes of Pyridoclax, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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