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PYZD-4409 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755430

PYZD-4409 causes cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells. PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 (IC50: 20uM (cell-free enzymatic assay)). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PYZD-4409, Inhibitor
Full Product Name
PYZD-4409
Product Gene Name
PYZD-4409, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
351.67
Solubility
DMSO: 35mg/mL (99.53mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C14H7ClFN3O5
SMILES
FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
CAS Number
423148-78-1
Target & IC50
ubiquitin-activating enzyme UBA1: ic50 20uM
In Vitro
PYZD-4409 (10mg/kg; intraperitoneal injection; daily on alternate days; for 16 days; male severe combined immunodeficient mice) reduces tumor weight and volume[1].

Structure of PYZD-4409, inhibitor

PYZD-4409 Inhibitor – Cat# MBS5755430

Product References and Citations for PYZD-4409, inhibitor

Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment,of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment,of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.

Other Notes

Small volumes of PYZD-4409, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PYZD-4409 purchase

MBS5755430 is an inhibitor targeting PYZD-4409.
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