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Quarfloxin Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755433

Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Quarfloxin, Inhibitor
Full Product Name
Quarfloxin
Product Synonym Names
CX-3543
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
604.67
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C35H33FN6O3
SMILES
O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
CAS Number
865311-47-3
Target & IC50
RNA pol I
In Vitro
Quarfloxin effectively inhibits the growth of neuroblastoma cells in vitro. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].

Structure of Quarfloxin, inhibitor

Quarfloxin Inhibitor – Cat# MBS5755433

Product References and Citations for Quarfloxin, inhibitor

Hald a˜H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.
Hald a˜H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.

Other Notes

Small volumes of Quarfloxin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Quarfloxin purchase

MBS5755433 is an inhibitor targeting Quarfloxin.
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