Remibrutinib Inhibitor

Name: Remibrutinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755445
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755445

Remibrutinib inhibits BTK activity with an IC50 value of 0.023uM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1nM). Remibrutinib has the potential for Chronic urticaria (CU) treatment. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Remibrutinib, Inhibitor

Full Product Name

Remibrutinib

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

507.53

Solubility

DMSO: 125mg/mL (246.29mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H27F2N5O3

SMILES

O=C(NC1=CC(F)=CC(C2=NC=NC(N)=C2OCCN(C)C(C=C)=O)=C1C)C3=CC=C(C4CC4)C=C3F

CAS Number

1787294-07-8

Target & IC50

BTK: ic50 1nM

Product Categories/Family for Remibrutinib, inhibitor

Angiogenesis; BTK; Tyrosine Kinase/Adaptors

Product References and Citations for Remibrutinib, inhibitor

Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
Kolkhir P, et al. New treatment, for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23.
Kolkhir P, et al. New treatment, for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23.

Other Notes

Small volumes of Remibrutinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Remibrutinib purchase

MBS5755445 is an inhibitor targeting Remibrutinib.