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RK-287107 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755464

RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6nM for tankyrase-1 and tankyrase-2, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RK-287107, Inhibitor
Full Product Name
RK-287107
Product Gene Name
RK-287107, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
416.46
Solubility
DMSO: 125mg/mL (300.15mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H26F2N4O2
SMILES
O=C1NC(N2CCC3(CC2)CN(CCO)C4=C3C(F)=CC(F)=C4)=NC5=C1CCCC5
CAS Number
2171386-10-8
Target & IC50
tankyrase-1: ic50 14.3nM
tankyrase-2: ic50 0.6nM
In Vitro
In a mouse xenograft model, RK-287107 (100 and 300mg/kg; i.p. administration; once per day; 5-days on/ 2-days off schedule for 2 weeks) inhibits tumor growth [1].

Structure of RK-287107, inhibitor

RK-287107 Inhibitor – Cat# MBS5755464

Product References and Citations for RK-287107, inhibitor

Mizutani A, et al. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. Cancer Sci. 2018 Dec;109(12):4003-4014.
Mizutani A, et al. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. Cancer Sci. 2018 Dec;109(12):4003-4014.

Other Notes

Small volumes of RK-287107, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RK-287107 purchase

MBS5755464 is an inhibitor targeting RK-287107.
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