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RO64-6198 Inhibitor – Ro 64-6198

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755470

Ro 64-6198 is a nonpeptide, high-affinity, and brain penetration N/OFQ receptor (NOP) agonist (EC50: 25.6nM). Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Ro 64-6198 (Ro64-6198), Inhibitor
Full Product Name
Ro 64-6198
Product Gene Name
Ro64-6198, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
401.54
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C26H31N3O
SMILES
O=C1NCN(C2=CC=CC=C2)C13CCN([C@H]4CC[C@]5([H])CCCC6=C5C4=CC=C6)CC3
CAS Number
280783-56-4
Target & IC50
Nociceptin receptor
In Vitro
Ro 64-6198 is anxiolytic in several neophobic tests at low doses, including the marble burying test in mice, the elevated plus-maze in rats, and the open field test in rats. In the marble burying test, Ro 64-6198 (1mg/kg, i.p.,) produces a decrease in the number of marbles buried, without altering locomotor activity, indicating a decrease in neophobia and anxiety. Ro 64-6198 (0.32-3mg/kg, i.p.,) selectively increases the number of open arm transitions and time spent in the open arms of the elevated plus-maze without affecting closed-arm transitions or locomotor activity in the closed arms. Ro 64-6198 (0.32-3mg/kg) attenuates the inhibition of exploration that results from the stress of a novel environment [1].

Structure of Ro64-6198, inhibitor

RO64-6198 Inhibitor – Cat# MBS5755470

Product References and Citations for Ro64-6198, inhibitor

Shoblock JR. The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity. CNS Drug Rev. 2007 Spring;13(1):107-36.
Shoblock JR. The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity. CNS Drug Rev. 2007 Spring;13(1):107-36.
Chang SD, et al. Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198). ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64.
Chang SD, et al. Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198). ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64.

Other Notes

Small volumes of Ro64-6198, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ro64-6198 purchase

MBS5755470 is an inhibitor targeting Ro64-6198. Also known as Ro 64-6198.
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