Rottlerin Inhibitor

Name: Rottlerin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755482
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755482

Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCdelta of 3-6uM, PKCalpha, beta, gamma of 30-42uM, PKCepsilon, eta, zeta of 80-100uM). Rottlerin causes apoptosis via caspase 3 activation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Rottlerin, Inhibitor

Full Product Name

Rottlerin

Product Synonym Names

Mallotoxin; NSC 56346; NSC 94525

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

516.54

Solubility

DMSO: 2mg/mL (3.87mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H28O8

SMILES

O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4

CAS Number

82-08-6

Target & IC50

PKCdelta: ic50 3uM (Porcine spleen)
PKCalpha: ic50 30uM (baculovirus-infected Sf9 insect cells)
PKCgamma: ic50 40uM (baculovirus-infected Sf9 insect cells)
PKCbeta: ic50 42uM (baculovirus-infected Sf9 insect cells)
PKCeta: ic50 82uM (baculovirus-infected Sf9 insect cells)
PKCzeta: ic50 100uM (baculovirus-infected Sf9 insect cells)
PKCepsilon: ic50 100uM (baculovirus-infected Sf9 insect cells)
CKII: ic50 0uM (holoenzyme expressed in E Coli)
PKA: ic50 78uM
CaM kinase III: ic50 5.3uM

In Vitro

Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3].

Product Categories/Family for Rottlerin, inhibitor

Cytoskeletal Signaling; PKC

Product References and Citations for Rottlerin, inhibitor

Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8.
Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8.
Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70.
Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70.
Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.
Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.

Other Notes

Small volumes of Rottlerin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rottlerin purchase

MBS5755482 is an inhibitor targeting Rottlerin.