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S1P1 Inhibitor – Agonist III

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755495

MBS5755495 is an inhibitor targeting S1P1. Also known as S1P1 Agonist III. S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18nM). More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
S1P1 Agonist III, Inhibitor
Full Product Name
S1P1 Agonist III
Product Gene Name
S1P1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
415.37
Solubility
DMSO: 62.5mg/mL (150.47mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H16F3N3O3
SMILES
COC1=CC=NC=C1C(NC(NC2=CC(C(F)(F)F)=C(C3=CC=CC=C3)C=C2)=O)=O
CAS Number
1324003-64-6
Target & IC50
Others
In Vitro
S1P1 agonist When dosed orally at 1 and 3mg/kg, S1P1 Agonist III achieved a statistically significant lowering of circulating blood lymphocytes 24 hours postdose. In rats, a dose-proportional increase in exposure was measured when S1P1 Agonist III was dosed orally at 2 and 100mg/kg. S1P1 Agonist III displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

Structure of S1P1, inhibitor

S1P1 Inhibitor – Cat# MBS5755495

Product References and Citations for S1P1, inhibitor

Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.
Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.

Other Notes

Small volumes of S1P1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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