SB-265610 Inhibitor

Name: SB-265610 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755508
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755508

SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7nM and 70nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SB-265610, Inhibitor

Full Product Name

SB-265610

Product Gene Name

SB-265610, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

357.16

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C14H9BrN6O

SMILES

N#CC1=C(N=NN2)C2=C(C=C1)NC(NC(C=CC=C3)=C3Br)=O

CAS Number

211096-49-0

Target & IC50

CXCR2

In Vitro

SB-265610 (100mg/kg/day;p.o; daily; for 5 days; CXCR2 wild type mice) treatment,markedly delays healing parameters in CXCR2 wild type mice during the wound repair process [2].

Product Categories/Family for SB-265610, inhibitor

Autophagy; CXCR; GPCR/G Protein; Immunology/Inflammation

Product References and Citations for SB-265610, inhibitor

Auten RL, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.
Auten RL, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.
Milatovic S, et al. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 May-Jun;11(3):213-9.
Milatovic S, et al. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 May-Jun;11(3):213-9.

Other Notes

Small volumes of SB-265610, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SB-265610 purchase

MBS5755508 is an inhibitor targeting SB-265610.