SCH-1473759 Inhibitor

Name: SCH-1473759 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755516
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755516

SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13nM for Aurora A and B, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SCH-1473759, Inhibitor

Full Product Name

SCH-1473759

Product Gene Name

SCH-1473759, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

426.54

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C20H26N8OS

SMILES

CC1=CN2C(C(NC3=CC(CN(C(C)(CO)C)CC)=NS3)=N1)=NC=C2C4=CNN=C4

CAS Number

1094069-99-4

Target & IC50

Aurora A: ic50 4nM
Aurora B: ic50 13nM

In Vitro

SCH-1473759 shows good exposure in all species with the clearance being high in rodents and moderate in dog and monkey. SCH 1473759 dose- and schedule-dependent anti-tumor activity in four human tumor xenograft models. SCH-1473759 at a low dose of 5mg/kg (i.p., bid) is well-tolerated in a continuous dosing schedule and shows 50% tumor growth inhibition(TGI) on day 16. A higher dose of 10mg/kg(i.p., bid) is well-tolerated in an intermittent schedule (5 days on, 5 days off) and gave 69% TGI on day 16. The half-life is also moderate, but tissue distribution is high [1][2].

Product Categories/Family for SCH-1473759, inhibitor

Cell Cycle/Checkpoint; Aurora Kinase; Chromatin/Epigenetic

Product References and Citations for SCH-1473759, inhibitor

Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.
Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.
Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.
Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.

Other Notes

Small volumes of SCH-1473759, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCH-1473759 purchase

MBS5755516 is an inhibitor targeting SCH-1473759.