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D-IN-1 Inhibitor – Complement Factor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755537

Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05uM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Complement factor D-IN-1, Inhibitor
Full Product Name
Complement factor D-IN-1
Product Gene Name
D-IN-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
483.32
Solubility
DMSO: 250mg/mL (517.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H19BrN6O3
SMILES
O=C(N)C1=NN(CC(N2[C@H](C(NC3=CC=CC(Br)=N3)=O)C[C@@H]4[C@H]2C4)=O)C5=C1C=CC=C5
CAS Number
1386455-76-0
Target & IC50
FD: ic50 0.006uM
MAC: ic50 0.05uM

Structure of D-IN-1, inhibitor

D-IN-1 Inhibitor – Cat# MBS5755537

Product References and Citations for D-IN-1, inhibitor

Lorthiois E, et al. Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D InhibitorsDemonstrating Alternative Complement Pathway Inhibition in Vivo. J Med Chem. 2017 Jul 13;60(13):5717-573
Lorthiois E, et al. Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D InhibitorsDemonstrating Alternative Complement Pathway Inhibition in Vivo. J Med Chem. 2017 Jul 13;60(13):5717-5735.

Other Notes

Small volumes of D-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for D-IN-1 purchase

MBS5755537 is an inhibitor targeting D-IN-1. Also known as Complement factor D-IN-1.
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