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SMER18 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755538

SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SMER18, Inhibitor
Full Product Name
SMER18
Product Gene Name
SMER18, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
287.74
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C16H14ClNO2
SMILES
C/C(NC1=CC=CC(O)=C1)=C/C(C2=CC=C(Cl)C=C2)=O
CAS Number
944153-47-3
Target & IC50
Others
In Vitro
SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models. mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively.

Structure of SMER18, inhibitor

SMER18 Inhibitor – Cat# MBS5755538

Product References and Citations for SMER18, inhibitor

Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.
Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.

Other Notes

Small volumes of SMER18, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMER18 purchase

MBS5755538 is an inhibitor targeting SMER18.
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