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SMURF1-IN-A01 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755541

Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Smurf1-IN-A01, Inhibitor
Full Product Name
Smurf1-IN-A01
Product Gene Name
Smurf1-IN-A01, inhibitor
Product Synonym Names
A01
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
512.93
Solubility
DMSO: 62.5mg/mL (121.85mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H20ClF3N4O3S
SMILES
O=S(C1=CC(C(F)(F)F)=C(Cl)C=C1)(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)=O
CAS Number
1007647-73-5
Target & IC50
Smurf1: ic50 3.664nM (kd)

Structure of Smurf1-IN-A01, inhibitor

SMURF1-IN-A01 Inhibitor – Cat# MBS5755541

Product References and Citations for Smurf1-IN-A01, inhibitor

Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.
Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.

Other Notes

Small volumes of Smurf1-IN-A01, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Smurf1-IN-A01 purchase

MBS5755541 is an inhibitor targeting Smurf1-IN-A01.
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