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Sortin1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755545

Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers. More details

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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Sortin1, Inhibitor
Full Product Name
Sortin1
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
441.43
Solubility
DMSO: 100mg/mL (226.54mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H19NO6
SMILES
O=C(C1=C(C)NC2=C(C(C3=C2C=CC=C3)=O)C1C4=CC=C(C5=CC=C(C(O)=O)C=C5)O4)OC
CAS Number
503837-98-7
Target & IC50
Others
In Vitro
Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. In Arabidopsis seedlings, the application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between vacuolar-flavonoid accumulations and vacuolar-biogenesis defects [1][2].

Structure of Sortin1, inhibitor

Sortin1 Inhibitor – Cat# MBS5755545

Product References and Citations for Sortin1, inhibitor

Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501.
Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501.
Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97.
Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97.
Orr DJ, et al. 1HnMR-based metabolomics methods for chemical genomics experiments. Methods Mol Biol. 2014;1056:225-39.
Orr DJ, et al. 1HnMR-based metabolomics methods for chemical genomics experiments. Methods Mol Biol. 2014;1056:225-39.

Other Notes

Small volumes of Sortin1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sortin1 purchase

MBS5755545 is an inhibitor targeting Sortin1.
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