SRPKIN-1 Inhibitor

Name: SRPKIN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755556
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755556

SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SRPKIN-1, Inhibitor

Full Product Name

SRPKIN-1

Product Gene Name

SRPKIN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

472.53

Solubility

DMSO: 110mg/mL (232.79mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H21FN2O3S

SMILES

O=S(C1=CC=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1)(F)=O

CAS Number

2089226-94-6

Target & IC50

SRPK1: ic50 35.6nM
SRPK2: ic50 98nM

In Vitro

SRPK-IN-1 effectively converts VEGF from pro-angiogenic to anti-angiogenic isoform. SRPKIN-1 treatment,at 200nM (10, 50, 100, 200nM, 16 hours) obviously decreases SR protein phosphorylation at the steady-state with or without washout [1].

Product Categories/Family for SRPKIN-1, inhibitor

Apoptosis; Serine/threonin kinase; Tyrosine Kinase/Adaptors

Product References and Citations for SRPKIN-1, inhibitor

Hatcher JM, et al. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6.
Hatcher JM, et al. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6.

Other Notes

Small volumes of SRPKIN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRPKIN-1 purchase

MBS5755556 is an inhibitor targeting SRPKIN-1.