SRT2183 Inhibitor – SRT 2183

MBS5755557 is an inhibitor targeting SRT2183. Also known as SRT 2183. SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36uM).

Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-kappaB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4(5): e635.
Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-kappaB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4(5): e635.
Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment,of type 2 diabetes. Nature. 2007 Nov 29; 450(7170): 712-716.
Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment,of type 2 diabetes. Nature. 2007 Nov 29; 450(7170): 712-716.

Small volumes of SRT2183, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.