SU16f Inhibitor

Name: SU16f Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755566
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755566

SU16f is a potent and selective PDGFRbeta inhibitor (IC50s: 10nM, 140nM, 2.29 uM for PDGFRbeta, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRbeta receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SU16f, Inhibitor

Full Product Name

SU16f

Product Gene Name

SU16f, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

386.44

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C24H22N2O3

SMILES

O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=CC=C4)=C3)=O)=C1C

CAS Number

251356-45-3

Target & IC50

PDGFRbeta: ic50 10nM
PDGFR2: ic50 140nM
PDGFR1: ic50 2.29uM

Product Categories/Family for SU16f, inhibitor

Angiogenesis; PDGFR

Product References and Citations for SU16f, inhibitor

Sun L, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.
Sun L, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.
Huang F, et al. Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression. J Cancer Res Clin Oncol. 2014 Nov;140(11):1835-48.
Huang F, et al. Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression. J Cancer Res Clin Oncol. 2014 Nov;140(11):1835-48.

Other Notes

Small volumes of SU16f, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SU16f purchase

MBS5755566 is an inhibitor targeting SU16f.