Tazemetostat hydrobromide Inhibitor

Name: Tazemetostat hydrobromide Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755593
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755593

Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tazemetostat hydrobromide, Inhibitor

Full Product Name

Tazemetostat hydrobromide

Product Synonym Names

EPZ-6438 hydrobromide; E-7438 hydrobromide

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

653.65

Solubility

DMSO: 100mg/mL (152.99mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C34H45BrN4O4

SMILES

O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O.[H]Br

CAS Number

1467052-75-0

Target & IC50

EZH2 WT: ic50
EZH2: ic50
Rat EZH2: ic50
EZH1: ic50

In Vitro

Tazemetostat (250 or 500mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors [1].

Product Categories/Family for Tazemetostat hydrobromide, inhibitor

Chromatin/Epigenetic; Histone Methyltransferase

Product References and Citations for Tazemetostat hydrobromide, inhibitor

Knutson SK, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferaseEZHProc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7.
Knutson SK, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferaseEZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7.

Other Notes

Small volumes of Tazemetostat hydrobromide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tazemetostat hydrobromide purchase

MBS5755593 is an inhibitor targeting Tazemetostat hydrobromide.