TC-I2014 Inhibitor – Tc-I 2014

Name: TC-I2014 Inhibitor; Tc-I 2014; MyBioSource
Brand: MyBioSource
SKU: MBS5755596
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755596

TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8nM, 3.0nM, and 4.4nM for canine, human and rat channels respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TC-I 2014 (TC-I2014), Inhibitor

Full Product Name

TC-I 2014

Product Gene Name

TC-I2014, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

467.41

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C23H19F6N3O

SMILES

FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F

CAS Number

1221349-53-6

Target & IC50

TRPM8

In Vitro

TC-I 2014 (10mg/kg, Orally once) fully avoids icilin-induced WDS [1].

Product Categories/Family for TC-I2014, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Product References and Citations for TC-I2014, inhibitor

Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.
Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.

Other Notes

Small volumes of TC-I2014, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TC-I2014 purchase

MBS5755596 is an inhibitor targeting TC-I2014. Also known as TC-I 2014.