TC-MPS1-12 Inhibitor

Name: TC-MPS1-12 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755597
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755597

TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TC-Mps1-12, Inhibitor

Full Product Name

TC-Mps1-12

Product Gene Name

TC-Mps1-12, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

324.38

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C17H20N6O

SMILES

N#CC1=C(N=C(NC2=CC=C(C(N)=O)C=C2)C=C1N)NC(C)(C)C

CAS Number

1206170-62-8

Target & IC50

Mps1: ic50 6.4nM

In Vitro

TC-Mps1-12 (25-100mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. TC-Mps1-12 (100mg/kg) treatment,shows 47% tumor growth inhibition without body weight loss. TC-Mps1-12 (p.o., 25mg/kg)treatment,displays good PK properties with a Cmax of 3542ng/mL and AUC of 6604 ng h/mL [1].

Product Categories/Family for TC-Mps1-12, inhibitor

Cytoskeletal Signaling; Kinesin

Product References and Citations for TC-Mps1-12, inhibitor

Kusakabe K, et al. Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett. 2012 Jun 6;3(7):560-4.
Kusakabe K, et al. Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett. 2012 Jun 6;3(7):560-4.

Other Notes

Small volumes of TC-Mps1-12, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TC-Mps1-12 purchase

MBS5755597 is an inhibitor targeting TC-Mps1-12.