Tolrestat Inhibitor

Name: Tolrestat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755642
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755642

Tolrestat is a potent and orally active inhibitor of aldose reductase (IC50: 35nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tolrestat, Inhibitor

Full Product Name

Tolrestat

Product Synonym Names

AY-27773

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

357.35

Solubility

DMSO: 100mg/mL (279.84mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H14F3NO3S

SMILES

O=C(O)CN(C(C1=C2C=CC(OC)=C(C(F)(F)F)C2=CC=C1)=S)C

CAS Number

82964-04-3

Target & IC50

Aldose Reductase: ic50 35nM

Product Categories/Family for Tolrestat, inhibitor

Endocrinology/Hormones; Reductase; Enzyme

Product References and Citations for Tolrestat, inhibitor

Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34(10):885-92.
Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802.

Other Notes

Small volumes of Tolrestat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tolrestat purchase

MBS5755642 is an inhibitor targeting Tolrestat.