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Tonapofylline Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755645

Tonapofylline is an orally active and selective adenosine A1 receptor antagonist (Ki: 7.4nM for human adenosine A1 receptor (hA1)). It shows 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tonapofylline, Inhibitor
Full Product Name
Tonapofylline
Product Synonym Names
BG 9928
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
416.51
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C22H32N4O4
SMILES
O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1
CAS Number
340021-17-2
Target & IC50
Human adenosine A1 receptor: ic50 7.4nM (ki)

Structure of Tonapofylline, inhibitor

Tonapofylline Inhibitor – Cat# MBS5755645

Product References and Citations for Tonapofylline, inhibitor

Ensor CR, et al. Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment,of heart failure. Expert Opin Pharmacother. 2010 Oct;11(14):2405-15.
Gill A, et al. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats. Am J Nephrol. 2009;30(6):521-6.

Other Notes

Small volumes of Tonapofylline, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tonapofylline purchase

MBS5755645 is an inhibitor targeting Tonapofylline.
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