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Trabectedin Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755653

Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Trabectedin, Inhibitor
Full Product Name
Trabectedin
Product Synonym Names
Ecteinascidin 743; ET-743
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
761.84
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C39H43N3O11S
SMILES
CC1=C(OCO2)C2=C([C@H](COC3=O)N4[C@]([C@@H]5SC[C@]63C(C=C(OC)C(O)=C7)=C7CCN6)([H])[C@@H]8N(C)[C@@H](CC9=CC(C)=C(OC)C(O)=C98)[C@@H]4O)C5=C1OC(C)=O
CAS Number
114899-77-3
Target & IC50
MX-1 cells: ic50 0.1nM
MCF7 cells: ic50 1.5nM
MCF7/DXR cells: ic50 3.7nM

Structure of Trabectedin, inhibitor

Trabectedin Inhibitor – Cat# MBS5755653

Product References and Citations for Trabectedin, inhibitor

Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.
Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.

Other Notes

Small volumes of Trabectedin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Trabectedin purchase

MBS5755653 is an inhibitor targeting Trabectedin.
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