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TX1-85-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755667

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TX1-85-1, Inhibitor
Full Product Name
TX1-85-1
Product Gene Name
TX1-85-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
580.68
Solubility
DMSO: 3.85mg/mL (6.63mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C32H36N8O3
SMILES
CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
CAS Number
1603845-32-4
Target & IC50
ErbB3: ic50 23nM

Structure of TX1-85-1, inhibitor

TX1-85-1 Inhibitor – Cat# MBS5755667

Product References and Citations for TX1-85-1, inhibitor

1. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

Other Notes

Small volumes of TX1-85-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TX1-85-1 purchase

MBS5755667 is an inhibitor targeting TX1-85-1.
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