UNC2541 Inhibitor

Name: UNC2541 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755680
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755680

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UNC2541, Inhibitor

Full Product Name

UNC2541

Product Gene Name

UNC2541, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

471.57

Solubility

DMSO: 10mg/mL (21.21mM) ultrasonic and warming and heat to 60 degree C
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H34FN7O2

SMILES

O=C(C(C(NCCCC[C@@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3

CAS Number

1612782-86-1

Target & IC50

Axl: ic50 120nM
Tyro3: ic50 220nM
Flt3: ic50 320nM; pMerTK: ic50 510nM (EC50)

Product Categories/Family for UNC2541, inhibitor

Tyrosine Kinase/Adaptors; TAM Receptor; Protein Tyrosine Kinase/RTK; Tyrosine Kinase/Adaptors

Product References and Citations for UNC2541, inhibitor

1. McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.

Other Notes

Small volumes of UNC2541, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UNC2541 purchase

MBS5755680 is an inhibitor targeting UNC2541.