Vecabrutinib Inhibitor

Name: Vecabrutinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755691
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755691

Vecabrutinib is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3nM and 2.2nM, respectively). Vecabrutinib displays an IC50 of 24nM for ITK. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vecabrutinib, Inhibitor

Full Product Name

Vecabrutinib

Product Synonym Names

SNS-062

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

529.92

Solubility

DMSO: 125mg/mL (235.88mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H24ClF4N7O2

SMILES

NC([C@@H]1[C@@H](N(CCC[C@H]2NC3=CC(C(F)(F)F)=CC(Cl)=C3)C2=O)CN(C4=NC=NC(N)=C4F)CC1)=O

CAS Number

1510829-06-7

Target & IC50

ITK: ic50 2.2nM (kd)
BTK: ic50 0.3nM (kd)

Product Categories/Family for Vecabrutinib, inhibitor

Metabolism; Others; Angiogenesis; Tyrosine Kinase/Adaptors

Product References and Citations for Vecabrutinib, inhibitor

Catherine A. Fabian, et al. Abstract 1207: SNS-062 demonstrates efficacy in chronic lymphocytic leukemia in vitro and inhibits C481S mutated Bruton tyrosine kinase. Cancer Research July 2017 Volume 77, Issue 13 Supplement

Other Notes

Small volumes of Vecabrutinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vecabrutinib purchase

MBS5755691 is an inhibitor targeting Vecabrutinib.