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Auglurant Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755703

Auglurant is a novel and selective mGlu5 antagonist (IC50: 11nM (rat) and an IC50: 14nM (human)). Auglurant has an acceptable CNS penetration. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Auglurant, Inhibitor
Full Product Name
Auglurant
Product Synonym Names
VU0424238
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
325.3
Solubility
DMSO: 22.73mg/mL (69.87mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C16H12FN5O2
SMILES
CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN=CN=C3)=C1
CAS Number
1396337-04-4
Target & IC50
Others

Structure of Auglurant, inhibitor

Auglurant Inhibitor – Cat# MBS5755703

Product References and Citations for Auglurant, inhibitor

Felts AS, et al. Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem. 2017 Jun 22;60(12):5072-5085.

Other Notes

Small volumes of Auglurant, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Auglurant purchase

MBS5755703 is an inhibitor targeting Auglurant.
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