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Ximelagatran Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755718

Ximelagatran, a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ximelagatran, Inhibitor
Full Product Name
Ximelagatran
Product Synonym Names
H 376/95; H37695; H-37695; H 37695; H 376/95; H 376-95; H 376-95
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
473.57
Solubility
DMSO: 250mg/mL (527.91mM) Need ultrasonic
Methanol: 62.5mg/mL (131.98mM) Need ultrasonic
Water: Insoluble
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)
Formula
C24H35N5O5
SMILES
O=C(OCC)CN[C@H](C1CCCCC1)C(N2[C@H](C(NCC3=CC=C(C=C3)/C=N/NO)=O)CC2)=O
CAS Number
192939-46-1
Target & IC50
Others

Product References and Citations for Ximelagatran, inhibitor

Keisu M, Andersson TB. Drug-induced liver injury in humans: the case of ximelagatran. Handb Exp Pharmacol. 2010;(196):407-18. doi: 10.1007/978-3-642-00663-0_13. Review. PubMed PMID: 20020269.
Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct;1(10):2119-30.
Gao JH, et al. Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis. Medicine (Baltimore). 2017 Oct;96(40):e8059.
Lazo-Langner A, Rodger MA, Wells PS. Lessons from ximelagatran: issues for future studies evaluating new oral direct thrombin inhibitors for venous thromboembolism prophylaxis in orthopedic surgery. Clin Appl Thromb Hemost. 2009 May-Jun;15(3):316-26. doi: 10.1177/1076029608326166. Review. PubMed PMID: 19028773.
Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.
Testa L, Bhindi R, Agostoni P, Abbate A, Zoccai GG, van Gaal WJ. The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile. Expert Opin Drug Saf. 2007 Jul;6(4):397-406. Review. PubMed PMID: 17688383.
Koscielny J, Kiesewetter H, Jorg I, Harenberg J. Ximelagatran for treatment, and prophylaxis of recurrent events in deep vein thrombosis. Clin Appl Thromb Hemost. 2007 Jul;13(3):299-307. Review. PubMed PMID: 17636192.

Other Notes

Small volumes of Ximelagatran, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ximelagatran purchase

MBS5755718 is an inhibitor targeting Ximelagatran.
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