XL228 Inhibitor

Name: XL228 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755720
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755720

XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

XL228, Inhibitor

Full Product Name

XL228

Product Gene Name

XL228, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

437.54

Solubility

DMSO: 83.33mg/mL (190.45mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H31N9O

SMILES

CN1CCN(C2=CC(NC3=NNC(C4CC4)=C3)=NC(NCC5=CC(C(C)C)=NO5)=N2)CC1

CAS Number

898280-07-4

Target & IC50

Aurora A: ic50 3.1nM
IGF-1R: ic50 1.6nM

Product Categories/Family for XL228, inhibitor

Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors

Product References and Citations for XL228, inhibitor

Douglas O, et al. Abstract C192: Characterization of the target profile of XL228, a multi-targeted protein kinase inhibitor in phase 1 clinical development. Mol Cancer Ther 2009;8(12 Suppl):C192.
Shah N, et al. Targeting Drug-Resistant CML and Ph+-ALL with the Spectrum Selective Protein Kinase Inhibitor XL228. Blood 2007 110:474

Other Notes

Small volumes of XL228, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XL228 purchase

MBS5755720 is an inhibitor targeting XL228.