Zaurategrast Inhibitor

Zaurategrast is an effective and oral-effective inhibitor of the alpha4-integrin.

Wolf C, et al. Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study. PLoS One. 2013;8(3):e58438.
Chanteux H, et al. In Vitro Hydrolysis and Transesterification of CDP323, an alpha4beta1/alpha4beta7 Integrin Antagonist Ester Prodrug. Drug Metab Dispos. 2014 Jan;42(1):153-61.
Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an alpha4beta1/alpha4beta7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91.

Small volumes of Zaurategrast, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5755729 is an inhibitor targeting Zaurategrast.