(-)-Indolactam V Inhibitor

Name: (-)-Indolactam V Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755734
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755734

(-)-Indolactam V is a PKC activator (Kis: 3.36nM, 1.03uM for eta-CRD2, gamma-CRD2). (-)-Indolactam V also has the Kds are 5.5nM (eta-C1B), 7.7nM (epsilon-C1B), 8.3nM (delta-C1B), 18.9nM (beta-C1A-long), 20.8nM (alpha-C1A-long), 137nM (beta-C1B), 138nM… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

(-)-Indolactam V, Inhibitor

Full Product Name

(-)-Indolactam V

Product Synonym Names

Indolactam V

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

301.38

Solubility

DMSO: 50mg/mL (165.90mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H23N3O2

SMILES

CC(C)[C@@H](C1=O)N(C)C2=C3C(NC=C3C[C@H](N1)CO)=CC=C2

CAS Number

90365-57-4

Target & IC50

PKCeta-CRD2: ic50 3.36nM (ki)
PKCeta-C1B: ic50 5.5nM (kd)
PKCepsilon-C1B: ic50 7.7nM (kd)
PKCdelta-C1B: ic50 8.3nM (kd)
PKCtheta-C1B: ic50 8.7nM (kd)
PKCbeta-C1A-long: ic50 18.9nM (kd)
PKCalpha-C1A-long: ic50 20.8nM (kd)
PKCbeta-C1B: ic50 137nM (kd)
PKCgamma-C1A: ic50 138nM (kd)
PKCgamma-C1B: ic50 213nM (kd)
PKCgamma-CRD2: ic50 1030nM (ki)
PKCdelta-C1A: ic50 1900nM (kd)
PKCeta-C1A: ic50 3770nM (kd)
PKCalpha-C1B-long: ic50 4000nM (kd)
PKCepsilon-C1A: ic50 4110nM (kd)

Product Categories/Family for (-)-Indolactam V, inhibitor

Cytoskeletal Signaling; PKC

Product References and Citations for (-)-Indolactam V, inhibitor

Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.
Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.

Other Notes

Small volumes of (-)-Indolactam V, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (-)-Indolactam V purchase

MBS5755734 is an inhibitor targeting (-)-Indolactam V.