CL2A-SN-38 Inhibitor

Name: CL2A-SN-38 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755750
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755750

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CL2A-SN-38, Inhibitor

Full Product Name

CL2A-SN-38

Product Gene Name

CL2A-SN-38, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

1480.61

Solubility

DMSO: 85mg/mL (57.4mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C73H97N11O22

SMILES

CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc(CNC(=O)C6CCC(CN7C(=O)C=CC7=O)CC6)nn5)cc4)c3=O)-c2nc2ccc(O)cc12

CAS Number

1279680-68-0

Target & IC50

Camptothecins

Product Categories/Family for CL2A-SN-38, inhibitor

PROTAC

Product References and Citations for CL2A-SN-38, inhibitor

Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment,of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.
Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment,of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Other Notes

Small volumes of CL2A-SN-38, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CL2A-SN-38 purchase

MBS5755750 is an inhibitor targeting CL2A-SN-38.