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Dihydrofluorescein diacetate Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755827

Dihydrofluorescein diacetate is a fluorimetric probe used for the measurements of oxidative stress. More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Dihydrofluorescein diacetate, Inhibitor
Full Product Name
Dihydrofluorescein diacetate
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
418.4
Solubility
DMSO: 106.5mg/mL (254.54mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H18O7
SMILES
O=C(O)C1=CC=CC=C1C2C3=C(OC4=C2C=CC(OC(C)=O)=C4)C=C(OC(C)=O)C=C3
CAS Number
35340-49-9
Target & IC50
Others
In Vitro
Dihydrofluorescein diacetate is a better fluorescent probe for detecting intracellular oxidants because it is more reactive toward specific oxidizing species. It shows fluorescence of linear structures, consistent with mitochondria, in reoxygenated endothelium [1]. Dihydrofluorescein diacetate is able to detect the presence of ROS in mitochondria. Dihydrofluorescein diacetate fluorescence was sharp and delineated thin filaments which corresponded in all details to TMRM-stained mitochondria. It enters mitochondria and reacts with ROS released in the matrix [2]. Dihydrofluorescein diacetate could be a useful and quantitative method for measuring the oxidative potential of nanoparticle-treated cells [3].

Structure of Dihydrofluorescein diacetate, inhibitor

Dihydrofluorescein diacetate Inhibitor – Cat# MBS5755827

Product References and Citations for Dihydrofluorescein diacetate, inhibitor

Hempel SL, et al. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 12Free Radic Biol Med. 1999 Jul;27(1-2):146-59.
Hempel SL, et al. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic Biol Med. 1999 Jul;27(1-2):146-59.
Diaz G, et al. Mitochondrial localization of reactive oxygen species by dihydrofluorescein probes. Histochem Cell Biol. 2003 Oct;120(4):319-25.
Diaz G, et al. Mitochondrial localization of reactive oxygen species by dihydrofluorescein probes. Histochem Cell Biol. 2003 Oct;120(4):319-25.
Aranda A, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954-63.
Aranda A, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954-63.

Other Notes

Small volumes of Dihydrofluorescein diacetate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dihydrofluorescein diacetate purchase

MBS5755827 is an inhibitor targeting Dihydrofluorescein diacetate.
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