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8pyDTZ Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755937

8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission and improved water solubility. It can be used for in vivo luminescence imaging. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
8pyDTZ, Inhibitor
Full Product Name
8pyDTZ
Product Gene Name
8pyDTZ, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
378.43
Solubility
EtOH+HCl: 2mg/mL (5.28mM) DMSO can inactivate 8pyDTZ's activity
H2O: <0.1mg/mL (insoluble) DMSO can inactivate 8pyDTZ's activity
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H18N4O
SMILES
O=C1C(CC2=CC=CC=C2)=NC3=C(C4=CC=NC=C4)NC(C5=CC=CC=C5)=CN31
CAS Number
2351898-91-2
Target & IC50
Others
In Vitro
LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice.

Structure of 8pyDTZ, inhibitor

8pyDTZ Inhibitor – Cat# MBS5755937

Product References and Citations for 8pyDTZ, inhibitor

Yeh HW, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965.
Yeh HW, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965.

Other Notes

Small volumes of 8pyDTZ, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 8pyDTZ purchase

MBS5755937 is an inhibitor targeting 8pyDTZ.
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