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PF-06273340 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756155

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6nM; Trk-B = 4nM; Trk-C = 3nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-06273340, Inhibitor
Full Product Name
PF-06273340
Product Gene Name
PF-06273340, inhibitor
Product Synonym Names
PF6273340; PF6273340; PF 6273340; PF-6273340; PF06273340; PF 06273340
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
479.93
Solubility
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)
Formula
C23H22ClN7O3
CAS Number
1402438-74-7

Product References and Citations for PF-06273340, inhibitor

Skerratt SE, Andrews MD, Bagal SK, Bilsland J, Brown D, Bungay PJ, Cole S, Gibson KR, Jones R, Morao I, Nedderman A, Omoto K, Robinson C, Ryckmans T, Skinner K, Stupple PA, Waldron G. The Discovery of a Potent, Selective and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the treatment,of Pain. J Med Chem. 2016 Oct 21. [Epub ahead of print] PubMed PMID: 27766865.

Other Notes

Small volumes of PF-06273340, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06273340 purchase

MBS5756155 is an inhibitor targeting PF-06273340.
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