Levoglucosenone Inhibitor

MBS5756178 is an inhibitor targeting Levoglucosenone. Levoglucosenone has cytotoxic. It against human hepatocarcinoma cell lines.

Sarnik J, Czubatka-Bienkowska A, Macieja A, Bielski R, Witczak ZJ, Poplawski T. The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-S-salicyl derivative and (1-4)-S-thio-disaccharides. Part 4. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1215-1219. doi: 10.1016/j. Bmcl.2017.01.064. Epub 2017 Jan 22. PubMed PMID: 28185719.
Krishna SH, Walker TW, Dumesic JA, Huber GW. Kinetics of Levoglucosenone Isomerization. ChemSusChem. 2017 Jan 10;10(1):129-138. doi: 10.1002/cssc.201601308. Epub 2016 Dec 13. PubMed PMID: 27863100.
Alves Costa Pacheco A, Sherwood J, Zhenova A, McElroy CR, Hunt AJ, Parker HL, Farmer TJ, Constantinou A, De Bruyn M, Whitwood AC, Raverty W, Clark JH. Intelligent Approach to Solvent Substitution: The Identification of a New Class of Levoglucosenone Derivatives. ChemSusChem. 2016 Dec 20;9(24):3503-3512. doi: 10.1002/cssc.201600795. Epub 2016 Nov 17. PubMed PMID: 27860452.
Peru AA, Flourat AL, Gunawan C, Raverty W, Jevric M, Greatrex BW, Allais F. Chemo-Enzymatic Synthesis of Chiral Epoxides Ethyl and Methyl (S)-3-(Oxiran-2-yl)propanoates from Renewable Levoglucosenone: An Access to Enantiopure (S)-Dairy Lactone. Molecules. 2016 Jul 29;21(8). pii: E988. doi: 10.3390/molecules21080988. PubMed PMID: 27483225.

Small volumes of Levoglucosenone, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.