12-Crown-4 Inhibitor

12-Crown-4 disrupts Abeta40 fibrils. 12-Crown-4 can enter into the hydrophobic core region and form competitive, hydrophobic interactions with key hydrophobic residues.

Wang YM, Ju XJ, Liu Z, Xie R, Wang W, Wu JF, Zhang YQ, Chu LY. Competitive molecular-/ion-recognition responsive characteristics of poly(N-isopropylacrylamide-co-benzo-12-crown-4-acrylamide) copolymers with benzo-12-crown-4 as both guest and host units. Macromol Rapid Commun. 2014 Jul;35(14):1280-6. doi: 10.1002/marc.201400054. Epub 2014 Apr 9. Erratum in: Macromol Rapid Commun. 2014 Dec;35(24):2101. PubMed PMID: 24719381.
Tripathi G, Ramanathan G. Structures and conformation of a benzo-12-crown-4 containing dipeptide. Biopolymers. 2015 May;104(3):148-55. doi: 10.1002/bip.22614. PubMed PMID: 25645572.
Agrawal N, Skelton AA. 12-Crown-4 Ether Disrupts the Patient Brain-Derived Amyloid-beta-Fibril Trimer: Insight from All-Atom Molecular Dynamics Simulations. ACS Chem Neurosci. 2016 Oct 19;7(10):1433-1441. Epub 2016 Aug 11. PubMed PMID: 27454141.
Reuter K, Buchner MR, Thiele G, von Hanisch C. Stable Alkali-Metal Complexes of Hybrid Disila-Crown Ethers. Inorg Chem. 2016 May 2;55(9):4441-7. doi: 10.1021/acs. Inorgchem.6b00267. Epub 2016 Apr 15. PubMed PMID: 27082743.

Small volumes of 12-Crown-4, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756186 is an inhibitor targeting 12-Crown-4.