Perthane Inhibitor

Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans, and also prevent the formation of spontaneous mammary carcinoma.

Reuber MD. Histopathology of carcinomas of the liver in mice fed perthane. Tumori. 1980 Jun 30;66(3):277-83. PubMed PMID: 6255646.
LEONE LA, HAHN HB Jr, MELLETTE SJ. Studies of the effect of perthane on spontaneous and transplanted mammary carcinoma in the C3H mouse. Cancer Res. 1958 Nov;18(10):1161-6. PubMed PMID: 13596957.
TALIAFERRO I, LEONE L. Inhibitory effect of perthane (2,2-bis-[para-ethyl-phenyl]-1,1-dichloroethane) on adrenocortical function in human subjects. N Engl J Med. 1957 Oct 31;257(18):855-60. PubMed PMID: 13477401.
FINNEGAN JK, HENNIGAR GR, SMITH RB Jr, LARSON PS, HAAG HB. Acute and chronic toxicity studies on 2,2-bis-(p-ethylphenyl)-1,1-dichloroethane (perthane). Arch Int Pharmacodyn Ther. 1955 Oct 15;103(4):404-18. PubMed PMID: 13283630.

Small volumes of Perthane, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756188 is an inhibitor targeting Perthane.