S-Methoprene Inhibitor

S-Methoprene is a juvenile insect growth hormone analog. It alters Ca 2+ signaling and redox activity of cytochrome oxidase and induces male sex differentiation.

Dhopeshwarkar AS, Nicholson RA. Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [(3)H]CP55940 and [(3)H]SR141716A binding and modification of WIN55212-2-dependent inhibition of synaptosomal l-glutamate release. Eur J Pharmacol. 2014 Jan 15;723:431-41. doi: 10.1016/j.ejphar.2013.10.059. Epub 2013 Nov 8. PubMed PMID: 24211785.
Dryden MW, Smith V, Davis WL, Settje T, Hostetler J. Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatment, of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months. Parasit Vectors. 2016 May 17;9(1):287. doi: 10.1186/s13071-016-1575-5. PubMed PMID: 27189592; PubMed Central PMCID: PMC4869298.
Knaus M, Abu-Madi MA, Ibarra-Velarde F, Kok DJ, Kusi I, Postoli R, Chester ST, Rosentel J, Alva R, Irwin J, Visser M, Winter R, Rehbein S. Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infections in cats. Vet Parasitol. 2014 Apr 28;202(1-2):18-25. doi: 10.1016/j.vetpar.2014.02.033. PubMed PMID: 24703071.
Rehbein S, Capari B, Duscher G, Keidane D, Kirkova Z, Petkevičius S, Rapti D, Wagner A, Wagner T, Chester ST, Rosentel J, Tielemans E, Visser M, Winter R, Kley K, Knaus M. Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe. Vet Parasitol. 2014 Apr 28;202(1-2):10-7. doi: 10.1016/j.vetpar.2014.02.032. PubMed PMID: 24703070.

Small volumes of S-Methoprene, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756196 is an inhibitor targeting S-Methoprene.