Equilenin Inhibitor

Equilenin is an equine estrogen found in the urine of pregnant mares. It is also a naturally fluorescent steroid, has a high binding affinity for human sex steroid-binding protein (SBP).

Uchida M, Ishibashi H, Yamamoto R, Koyanagi A, Kusano T, Tominaga N, Ishibashi Y, Arizono K. Endocrine-disrupting potentials of equine estrogens equilin, equilenin, and their metabolites, in the medaka Oryzias latipes: in silico and DNA microarray studies. J Appl Toxicol. 2015 Sep;35(9):1040-8. doi: 10.1002/jat.3098. Epub 2015 Jan 22. PubMed PMID: 25611945.
Jinno A, Maruyama Y, Ishizuka M, Kazusaka A, Nakamura A, Fujita S. Induction of cytochrome P450-1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand. J Steroid Biochem Mol Biol. 2006 Jan;98(1):48-55. Epub 2005 Sep 26. PubMed PMID: 16191477.
Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chem Biol Interact. 2012 Mar 5;196(1-2):1-10. doi: 10.1016/j.cbi.2012.01.004. Epub 2012 Jan 28. PubMed PMID: 22290292; PubMed Central PMCID: PMC3319273.
Numazawa M, Osawa Y. Equilin and equilenin biosynthesis. Stereochemistry of aromatization of 3-hydroxy-3,5,7-androstatrien-17-one by horse placenta. J Steroid Biochem. 1987 Jan;26(1):137-43. PubMed PMID: 3821102.

Small volumes of Equilenin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756205 is an inhibitor targeting Equilenin.