Piretanide Inhibitor

Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.

Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD. Blood pressure-lowering efficacy of loop diuretics for primary hypertension. Cochrane Database Syst Rev. 2015 May 22;(5):CD003825. doi: 10.1002/14651858.CD003825.pub4. Review. PubMed PMID: 26000442.
Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD. Blood pressure lowering efficacy of loop diuretics for primary hypertension. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD003825. doi: 10.1002/14651858.CD003825.pub3. Review. Update in: Cochrane Database Syst Rev. 2015;(5):CD003825. PubMed PMID: 22895937.
Musini VM, Wright JM, Bassett K, Jauca CD. Blood pressure lowering efficacy of loop diuretics for primary hypertension. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD003825. doi: 10.1002/14651858.CD003825.pub2. Review. Update in: Cochrane Database Syst Rev. 2012;8:CD003825. PubMed PMID: 19821314.
Knauf H, Mutschler E. Clinical pharmacokinetics and pharmacodynamics of torasemide. Clin Pharmacokinet. 1998 Jan;34(1):1-24. Review. PubMed PMID: 9474471.

Small volumes of Piretanide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756213 is an inhibitor targeting Piretanide.